Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free: https://www.ghostery.com/fr/products/

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site: http://www.youronlinechoices.com/fr/controler-ses-cookies/, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Realytics
Google Analytics
Spoteffects
Optimizely

Targeted advertising cookies

DoubleClick
Mediarithmics

The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at cil-dpo@inra.fr or by post at:

INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

CarbOptiMus

.
CARBOPTIMUS

Optimization of the muscle mass preservation by a chrono-nutrition dissociated from the meal. Frail elderdies as a model.

                                                                                      

Background                             

Solving the problems associated with aging will be one of the major issues of human nutrition research in the coming decades. In the new Auvergne-Rhône-Alpes Region, 25% of the population is 60 years old or older. The number of potentially dependent elderly people is likely to increase, reaching 30% of the population by 2030.

One of the factors that explains this phenomenon is the loss of muscle mass and function occurring from the fifth decade in humans. Muscle wasting has a multifactorial origin including decreased physical activity, malnutrition / undernutrition and loss of post-incident muscle recovery abilities. Among the strategies tested as relevant for improving the production of proteins and therefore muscle, is the supplementation of whey meals (fast milk proteins). However, this strategy does not seem sufficient to prevent muscle wasting and must be combined with complementary action. Indeed, the breakdown of muscle proteins also occurs during the periods of nocturnal fasting so as to provide amino acids for energy purposes and thus produce glucose. The preservation of the benefit of whey intake during meals could therefore be optimized by reducing the use of muscle proteins for energy purposes during the night.

Objective

The CarbOptiMus project is therefore a "proof of concept" that consists of verifying whether protein-energy chrononutrition would optimize the preservation of lean and muscular mass in situations of muscle wasting and recovery in the frail elderly person in an institution. The project consists of studying for 3 months: 1 control group, 1 group with whey supplementation at noon, and 1 group with whey supplementation at noon and an energy bolus before bedtime. Actions include weight and body composition monitoring, nutritional status and muscle function, as well as mechanistic analyzes using non-invasive "omic" approaches (fluids and circulating cells). The innovative character is based on the coupling of the optimization of the muscle protein anabolism during the midday meal with the protective effect of the energy bolus on the loss of proteins and muscles during the night. This strategy of protein-energy chrono-nutrition has never been tested to our knowledge.

Consortium

The CarbOptiMus consortium is composed of researchers with recognized expertise and know-how in the field of nutrition (Human Nutrition Unit, INRA Clermont-Ferrand) and translational research in the elderly (CHU St-Etienne). The project was also labeled by the Térralia competitiveness cluster and supported by the nutrition-nutrition-health cluster Nutrativa and the Vallée cereals competitiveness cluster, as well as by several socio-economic players in the new AuRA region.

Impact

The impact and benefits of the project can be divided into 3 parts:

1) The development of a food supply for the frail elderly, adapted to their needs and based on a matrix that will allow a natural and targeted oral feeding to reduce the metabolic consequences of too long periods of fasting often seen in geriatric institutions.

2) The development of an early diagnosis tool on a simple blood test or urine. This would allow a rapid, economical and customizable way to follow the favorable evolution of the state of health and the decline of the state of undernutrition of the elderly thanks to the biomarkers identified during our "omic" type approach.

3) The impact on economic actors, including the use of natural matrices and "health" to convey the energy bolus, the optimization of institutional nutrition, the development of new food products fortified with whey and / or maltodextrin for targeted and specific populations, the valorization of by-products such as whey in human nutrition and the optimization of such matrices for the elderly according to their state of health and fragility.