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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal logo Université Clermont Auvergne & associés

Human Nutrition Unit

Zone de texte éditable et éditée et rééditée

Dr Dominique DARDEVET


         Research Activities          Publications          Curriculum vitae

Publications 2013-2018

PUBMED  Full List


PUBMED Full List

Peyron M.-A., V. Santé-Lhoutellier, D. Dardevet, M. Hennequin,, D. Rémond, O. François, A. Woda  Adressing various challenges related to food bolus and nutrition with the mastication simulator AM2. Food Hydrocolloids, 2019  

O'Keeffe M, Kelly M, O'Herlihy E, O'Toole PW, Kearney PM, Timmons S, O'Shea E, Stanton C, Hickson M, Rolland Y, Sulmont Rossé C, Issanchou S, Maitre I, Stelmach-Mardas M, Nagel G, Flechtner-Mors M, Wolters M, Hebestreit A, De Groot LCPGM, van de Rest O, Teh R, Peyron MA, Dardevet D, Papet I, Schindler K, Streicher M, Torbahn G, Kiesswetter E, Visser M, Volkert D, O'Connor EM; MaNuEL consortium.Potentially modifiable determinants of malnutrition in older adults: A systematic review. Clinical  Nutrition.

Poupin N, M Tremblay-Franco, A Amiel, C Canlet, D Rémond, L Debrauwer, D Dardevet, I Thiele, MK. Aurich, F Jourdan, I Savary-Auzeloux, S Polakof Arterio-venous NMR-based metabolomics exploration reveals major changes across liver and intestine in the obese minipig  Scientific Reports 2019

Correa-Pérez A, Abraha I, Cherubini A, Collinson A, Dardevet D, de Groot LC, de van der Schueren MAE, Hebestreit A, Hickson M, Jaramillo-Hidalgo J, Lozano-Montoya I, O'Mahony D, Soiza RL, Visser M, Volkert D, Wolters M, Jentoft AJC. Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project. Ageing Res Rev.

Le Bacquer O, Combe K, Patrac V, Ingram B, Combaret L, Dardevet D, Montaurier C, Salles J, Giraudet C, Guillet C, Sonenberg N, Boirie Y, Walrand S. 4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia. J Cachexia Sarcopenia Muscle 2019

Mast C, Dardevet D, Papet I. Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case. Nutr Res Rev. 2018

Mohamed AB, D Rémond, C Chambon, T Sayd, M Hebraud, F Capel, B Cohade, N Hafnaoui, D Bechet, C Coudy-Gandilhon, C Migné, J David, D Dardevet, J Doré, S Polakof, I Savary-Auzeloux.    A mix of dietary fibers improves lipids handling by the liver of overfed minipigs.  J Nutr Biochem. 2019

Cholewa J,  D Dardevet,  Lima Soares F, , K Pessôa, PH Oliveira,  J R Dos Santos Pinho, H Nicastro, Z Xia, C Emmanuel Torres Cabido,NE Zanchi. Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: Role of the MPS response. Aminoacids 2017

Mosoni L, M Jarzaguet, J David, S Polakof, I Savary-Auzeloux, D Rémond, D Dardevet. Post meal energy boluses do not increase the duration of muscle protein synthesis stimulation in two anabolic resistant situations. Nutrients 2019

Bordoni A, F Danesi, D Dardevet, D Gille, L Author, C Nunes Dos Santos, P Pinto, R Re, D Remond, D Shakar, G Vergeres. Dairy Products and Inflammation: A Review of the Clinical Evidence Crit Rev Food Sci Nutr. 2017

Savary-Auzeloux I., Mohamed A.B., Cohade B., Dardevet D., David J., Hafnaoui N., Migne  C. , Pujos-Guillot E., Rémond D.1, Polakof S. Profound Changes in Net Energy and Nitrogen Metabolites Fluxes within the Splanchnic Area during Overfeeding of Yucatan Mini Pigs That Remain Euglycemic. Nutrients. 2019

Gatineau E, S Polakof, D Dardevet, L Mosoni. Similarities and interactions between the aging process and high chronic intake of added sugars. Nutrition Research Reviews, 2017

David J, D Dardevet; L Mosoni; I Savary-Auzeloux; S Polakof Impaired skeletal muscle branched-chain amino acids catabolism contributes to their increased circulating levels in a non-obese insulin resistant fructose-fed rat model. Nutrients,  2019

Wester T, Kraft G D Dardevet, S Polakof, I Ortigues-Marty, D Rémond, I Savary- Auzeloux. Nutritional regulation of the anabolic fate of amino acids within the liver in mammals. Concepts arising from in vivo studies.  Nutrition Research  Reviews, 2015

Jarzaguet M, Polakof S, David J, Migné C, Joubrel G, Efstathiou T, Rémond D, Mosoni  L and Dardevet D . A meal with mixed soy/whey proteins is as efficient as a whey meal in counteracting the aged-related muscle anabolic resistance only if protein content and leucine levels are increased. Food Funct. 2018

Magne H,  Savary-Auzeloux I, Remond  d and D Dardevet Nutritional strategies to counteract disuse muscle atrophy and improve following recovery. Nutrition Research Reviews 2013

Polakof S, D Rémond, J David, D Dardevet, I Savary-Auzeloux. Time-course changes in circulating branched-chain amino acid levels and metabolism in obese Yucatan minipig? Nutrition 2018

Zeng Y, J David, D Rémond, D Dardevet, I Savary-Auzeloux, S Polakof. Peripheral blood mononuclear cells metabolism adapted acutely to the postprandial transition and reflected mainly the adipose tissue metabolic adaptations to a high fat fed diet in minipigs. Nutrients, 2018

Polakof S; D Rémond; A Bernalier-Donadille; M Rambeau; E Pujos-Guillot; B Comte; D Dardevet;  Savary-Auzeloux.  Metabolic adaptations to HFHS overfeeding: How whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs" European Journal of Nutrition

Xia Z, Cholewa JM, Dardevet D, Huang T, Zhao Y, Shang H, Yang Y, Ding X, Zhang C, Wang H, Liu S, Su Q, Zanchi NE. Effects of oat protein supplementation on skeletal muscle damage, inflammation and performance recovery following downhill running in untrained collegiate men. Food Funct. 2018

Pujos-Guillot E, Brandolini-Bunlon M, Fouillet H, Joly C, Martin JF, Huneau JF, Dardevet D, Mariotti F. Metabolomics Reveals that the Type of Protein in a High-Fat Meal Modulates Postprandial Mitochondrial Overload and Incomplete Substrate Oxidation in Healthy Overweight Men. J Nutr. 2018

Bidu C, S Bellenger, A Spor, M Galan, A Geissler, D Dardevet, B Morio-LiondorE, Cani, L Lagrost, M Narce, J Bellenger. The transplantation of w3 PUFA-altered gut microbiota of fat-1 mice to wild-type littermates prevents obesity and associated metabolic disorders. Diabetes 2018 

Gatineau E, S Cluzet, S Krizac, I Papet C Migné, D Rémond, D Dardevet, S Polakof, T Richard, L Mosoni.  Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients. Journal of Physiology and Biochemistry, 2018. 

Gatineau E,  Cluzet S,  Krisa S, Papet I,   Migné C,   Rémond D,  Dardevet D,  Polakof S,  Richard T  and Mosoni L. Effect of nutritional state, aging and high chronic intake of sucrose on brain protein synthesis in rats, Modulation by rutin and other micronutrients. Food Funct , 2018

Polakof S, D Rémond, J David, D Dardevet, I Savary-Auzeloux. Time-course changes in circulating branched-chain amino acid levels and metabolism in obese Yucatan minipig? Nutrition, 2018

Dardevet D. Protéines Laitières et Sarcopénie. Actualités en Diététique et Nutrition 2015,

Dardevet D, Mosoni L, David J, Polakof S. Fructose Feeding during the Postabsorptive State Alters Body Composition and Spares Nitrogen in Protein-Energy-Restricted Old Rats.  J Nutr. 2018

D. Dardevet, L. Mosoni, M.-A. Peyron, I. Papet, D. Rémond, I. Savary-Auzeloux. Pour des stratégies nutritionnelles efficaces contre la sarcopénie au cours du vieillissement: le seuil anabolique musculaire. 2014 LA REVUE FRANCOPHONE DE GÉRIATRIE ET DE GÉRONTOLOGIE,  TOME XXI , N°206

Verney J, Martin V, Ratel S, Chavanelle V, Bargetto M, Etienne M, Chaplais E, Le Ruyet P, Bonhomme C, Combaret L, Guillet C, Boisseau N, Sirvent P, Dardevet D.  Soluble Milk Proteins Improve Muscle Mass Recovery after Immobilization-Induced Muscle Atrophy in Old Rats but Do not Improve Muscle Functional Property Restoration. J Nutr Health Aging. 2017

Revel A, Jarzaguet M, Peyron MA, Papet I, Hafnaoui N, Migné C, Mosoni L, Polakof S, Savary-Auzeloux I, Rémond D, Dardevet D.At same leucine intake, a whey/plant protein blend is not as effective as whey to initiate a transient post prandial muscle anabolic response during a catabolic state in mini pigs. PLoS One. 2017

Dardevet D.  Sarcopénie et protéines alimentaires: Lesquelles? Comment ? Seules? Les Carrefours de l'Innovation Agronomique (CIAG) : L'alimentation des séniors et le bien vieillir ; Dijon, Novembre 2013

Barquissau V, Capel F, Dardevet D, Feillet-Coudray C, Gallinier A, Chauvin MA, Rieusset J, Morio B. Reactive oxygen species enhance mitochondrial function, insulin sensitivity and glucose uptake in skeletal muscle of senescence accelerated prone mice SAMP8. Free Radic Biol Med. 2017 

Dardevet D, Rémond D,  Peyron MA, Papet I, Savary-Auzeloux I and Mosoni L. Muscle wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia. Special Issue “Skeletal Muscle Physiology” – The Scientific World Journal Volume 2012 (2012), Article ID 269531

Buffière C, C Gaudichon, N Hafnaoui, C Migné, V Scislowsky, N Khodorova, L Mosoni, A Blot, Y Boirie, D Dardevet, V Santé-Lhoutellier, D Rémond In the elderly, meat protein assimilation from rare meat is lower than that from meat that is well done.. American Journal of Clinical Nutrition.2017

Mast C., C. Pourpre, G. Voyard , D. Rémond, C. Migné, D. Centeno, D. Dardevet, I. Savary-Auzeloux  and I. Papet. Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats. British Journal of Nutrition, 2017

Kraft G, KC. Coate, J Winnick, D Dardevet, PE. Donahue, AD. Cherrington, PE. Williams and MC Moore. Glucagon’s effect on liver protein metabolism in vivo. American Journal of Physiology. 2017

Chavanelle V, N Boisseau, YF Otero, L Combaret, D Dardevet, C Montaurier, G Delcros, S Peltier, P Sirvent Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice. Scientific Reports, 2017

Mast C, Savary-Auzeloux I, Rémond D, Pouyet C, Centeno D, Voyard G, Combaret L, Dardevet D & Papet I. RRepeated cures with paracetamol worsen sarcopenia in old rats with suboptimal food intake. J Physiol Pharmacol 2016

Polakof S, D Dardevet, M Larquier, L Mosoni,  E Gatineau, JF Martin, E Pujos-Guillot, A Mazur, B Comte The time course of molecular and metabolic events in the development of insulin resistance in fructose-fed rats. J Proteome Res. 2016 

Polakof S; D Rémond; A Bernalier-Donadille; M Rambeau; E Pujos-Guillot; B Comte; D Dardevet; I Savary-Auzeloux.  Metabolic adaptations to HFHS overfeeding: How whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs" European Journal of Nutrition, 2016 

Caillaud K, N Boisseau,  G Ennequin, V Chavanelle, M Etienne, X Li, P Denis, D Dardevet, A Lacampagne, P Sirvent. Neuregulin1 improves glucose tolerance in adult and aged rats. Diabetes and Metabolism, 2016

Pouget M, M Peyrot, P Denis, J Vuichoud, D Dardevet, K Vidal, D Breuillé, I Papet. Long-term dietary supplementation with cystathionine improves tissue glutathione in ageing rats. Aging Clinical and Experimental Research.2016

Polakof S, D Rémond, M Rambeau, E Pujos-Guillot, JL Sébédio, D Dardevet, B Comte, I Savary-Auzeloux. New insights from plasma metabolomics to characterize kinetically postprandial events: a mini-pig model. Metabolomics 2015

Mast C, B Lyan, C Joly, D Centeno, Giacomoni F, JF Martin, L Mosoni, D Dardevet, E Pujos-Guillot, I Papet.  Assessment of protein alterations in liver of rats under chronic treatment with paracetamol (acetaminophen) using two complementary mass spectrometry-based metabolomic approaches. J Proteomics.

Gatineau E, I savary-Auzeloux, C Migné, S Polakof, D Dardevet, L Mosoni. Chronic intake of sucrose accelerates sarcopenia in rats through alterations in insulin sensitivity and muscle protein synthesis. J Nutr. 2015

Slimani  L, E Vazeille , C Deval , B Meunier , C Polge , D Dardevet , D Béchet, D Taillandier , D Micol , A Listrat , D Attaix , L Combaret The induction of Sparc and β-catenin is associated with a temporal regulation of myogenic factors in rat muscle during post-immobilization recovery. J Cachexia Sarcopenia Muscle. 2015

Buffière C,  F Mariotti,  I Savary-Auzeloux,  C Migné, S Hercberg, N Cano,  D Rémond, M Duclos and D Dardevet Healthy old men with slight elevation of C Reactive Protein have lower global physical performances but similar fasting and postprandial muscle protein metabolism. Journal of Physiology-London, 2015

Gallot Y, AC Durieux, J Castells, B Vernus, L Plantureux, E Lefai, D Dardevet, D Rémond L Schaeffer, G Nemoz, A Bonnieu and D Freyssenet. Myostatin gene inactivation induces resistance to skeletal muscle loss and increases survival in mouse models of cancer cachexia. Cancer Research  2014

Mosoni  L, Gatineau  E, Gatellier  P, Migné  C, Savary-Auzeloux  I, Rocher E,  Rémond D and Dardevet  D High protein intake delayed the loss of lean body mass in healthy old rats, whereas protein type and polyphenol / antioxidant supplementation had no effects. PlosOne, 2014

Mast C, C Joly, I Savary-Auzeloux, D Rémond, D Dardevet, I Papet Skeletal muscle wasting occurs in adult rats chronically treated with paracetamol (acetaminophen) when GSH-dependent detoxification is highly activated. Journal of Physiology and Pharmacology, 2014

Magne, H ;  Savary-Auzeloux, I ; Migné, C;  Peyron, MA ; Combaret, L ; Mosoni L., Rémond, D and Dardevet, D. During ageing, unilateral casting induced a generalized muscle mass loss during rehabilitation prevented by a whey or a high protein diet but not a free leucine. PlosOne, 2013

Martin V, S Ratel, J Siracusa, P. LERUYET,  I Savary-Auzeloux, L Combaret, C Guillet and  D Dardevet. Leucine-rich proteins are more efficient than casein in the recovery of muscle functional properties following a casting induced muscle atrophy. PlosOne,, 2013

Polakof S, ME Diaz-Rubio, D Dardevet, JF Martin, E Pujos-Guillot, A Scalbert, JL Sebedio, A Mazur, and B Comte Resistant starch intake partly restores metabolic and inflammatory alterations in the liver of high-fat diet fed rats. Journal of Nutritional Biochemistry, 2013

Savary-Auzeloux  I,  Magne H,  Migné C. Oberli  M, Breuilé D., Faure  M., Vidal K, Perrot P, Combaret L, Rémond D and Dardevet D. A sequential dietary supplementation in leucine and antioxidants accelerates muscle mass recovery after immobilization in adult rats. PlosOne, 2013,

Bax ML; C Buffière; N Hafnaoui; C Gaudichon; I Savary-Auzeloux; D Dardevet; Vé Santé-Lhoutellier; D Rémond. "Effects of meat cooking, and of ingested amount, on protein digestion speed and entry of residual proteins into the colon: a study in minipig. ". PlosOne,2013

Dardevet D. Rémond D, Mosoni L Les protéines laitières : la source protéique à privilégier pour maintenir le capital musculaire des personnes âgées? Innovations Agronomiques 13 (2011), 47-57

Balage M and Dardevet D. Long-term effects of leucine supplementation on body composition.? Current Opinion in Clinical Nutrition and Metabolic Care. 2010

Combaret L, D Dardevet, D Béchet, D Taillandier, L Mosoni, and D Attaix. Skeletal Muscle Proteolysis in Aging. Current Opinion in Clinical Nutrition and Metabolic Care. 2009

Dardevet, D;  Moore, MC;  Rémond, D; Everett-Grueter, CA et  Cherrington AD. Regulation of hepatic metabolism by enteral (portal) delivery of nutrients.  Nutrition Research Reviews 2006

RIEU, I.,  MOSONI, L., COMBARET, L., SORNET, C., GRIZARD, J. et DARDEVET, D. Leucine and age-associated sarcopenia. Bulletin de l’Académie Véterinaire de France. 2006

ATTAIX, D., MOSONI, L., DARDEVET, D., COMBARET, L., PATUREAU MIRAND, P.  et GRIZARD, J. Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods. International Journal of Biochemistry & Cell Biology 2005

PROD'HOMME, M., RIEU, I., BALAGE, M., DARDEVET, D. et GRIZARD, J. Insulin and amino acids both strongly participate to the regulation of protein metabolism. Current Opinion in Clinical Nutrition and Metabolic Care, 2004

DARDEVET, D., RIEU, I., FAFOURNOUX, P., SORNET, C., COMBARET, L., BRUHAT, A., MORDIER, S., MOSONI, L. et GRIZARD, J. Leucine: a key amino acid in ageing-associated sarcopenia? Nutrition Research Reviews, 2003

GrizARD, J., DARDEVET, D., SAVARY, I., MOSONI, L., MEYNIAL-DENIS, D., ARNAL, M.A. et PATUREAU MIRAND, P. Implication de l'insuline et des glucocorticoïdes dans la fonte protéique musculaire chez le rat au cours du vieillissement. Age et Nutrition, 2001

GRIZARD, J., DARDEVET, D., PAPET, I., MOSONI, L., PATUREAU MIRAND, P., ATTAIX, D., TAUVERON, I., BONIN, D. et ARNAL, M. Nutrient regulation of skeletal muscle protein metabolism in animals. The involvement of hormones and substrates.  Nutrition Research Reviews, 1995